Arctic Front Advance™ Cryoballoon
Improving outcomes that matter to Patients, Clinicians, and the Healthcare System

Secondary analyses from the FIRE AND ICE trial demonstrated significant improvements that favor the Cryoballoon group over RFC for clinically meaningful outcomes including:

  • All-cause hospitalizations
  • Cardiovascular hospitalizations* (including AF hospitalizations†)
  • Repeat ablations*
  • Direct current cardioversions

Read the Full Manuscript

Significantly Fewer All-cause Hospitalizations
and Cardiovascular (CV) Hospitalizations with
Cryoballoon Compared to Radiofrequency

Fire and Ice Hospitalizations Chart

Significantly Fewer Repeat Ablations with
Cryoballoon Compared to Radiofrequency

Most Frequently Observed Chart

Freedom from Cardiovascular
Hospitalizations Subgroup Analysis
of Patient Baseline

Freedom From Hospitalizations Image 1 Freedom From Hospitalizations Image 2

*Predefined secondary analyses
†Not predefined but included in analyses


  1. Kuck KH, et al. Cryoballoon or radiofrequency ablation for symptomatic paroxysmal atrial fibrillation: reintervention, rehospitalization, and quality-of-life outcomes in the FIRE AND ICE trial. Eur Heart J (2016) First published online: 5 July 2016